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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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35 hot topic(s) found with the query "Multiple sclerosis"

Estimating individual treatment effect on disability progression in multiple sclerosis using deep learning.
Falet Jean-Pierre R et al. Nature communications 2022 9 (1) 5645 (Posted: Sep 28, 2022 8AM)

Disability progression in multiple sclerosis remains resistant to treatment. The absence of a suitable biomarker to allow for phase 2 clinical trials presents a high barrier for drug development. We propose to enable short proof-of-concept trials by increasing statistical power using a deep-learning predictive enrichment strategy.

Persistently reduced humoral and cellular immune response following third SARS-CoV-2 mRNA vaccination in anti-CD20-treated multiple sclerosis patients
HM Bajwa et al, MEDRXIV, January 28, 2022 (Posted: Jan 29, 2022 10AM)

Cellular and humoral immune responses following SARS-CoV-2 mRNA vaccination in patients with multiple sclerosis on anti-CD20 therapy
SA Apostolides et al, Nature Medicine, September 14, 2021 (Posted: Sep 14, 2021 7AM)

Ensemble learning predicts multiple sclerosis disease course in the SUMMIT study
Y Zhao et al, NPJ Digital Medicine, October 16, 2020 (Posted: Oct 17, 2020 0PM)

The rate of disability accumulation varies across multiple sclerosis (MS) patients. Machine learning techniques may offer more powerful means to predict disease course in MS patients.

Summary-data-based mendelian randomization reveals druggable targets for multiple sclerosis
BM Jacobs et al, BioRXIV preprints, January 25, 2020 (Posted: Jan 26, 2020 7AM)

Multiple Sclerosis is a complex autoimmune disease caused by a combination of genetic and environmental factors. Translation of Genome-Wide Association Study findings in MS into therapeutics and effective preventive strategies has been limited to date. We used Summary Data-Based Mendelian Randomization to synthesize findings from public databases.

Unraveling susceptibility to multiple sclerosis
F Briggs, Science, September 27, 2019 (Posted: Sep 28, 2019 8AM)

New studies numerous autosomal variants and the first X chromosome variant associated with MS susceptibility. These studies add resolution to the known function of adaptive immune responses and suggest a prominent role for dysregulation in multicellular innate immune processes in the narrative of MS susceptibility.

Research Uncovers How Commensal Bacteria Contribute to Multiple Sclerosis
T Hampton, JAMA, August 7, 2018 (Posted: Aug 09, 2018 0PM)

Towards personalized therapy for multiple sclerosis: prediction of individual treatment response.
Kalincik Tomas et al. Brain : a journal of neurology 2017 Sep 140(9) 2426-2443 (Posted: Nov 01, 2017 9AM)

Gut germs play role in multiple sclerosis, studies show. Are probiotics for MS next?
S Begley, StatNews, Sep 11, 2017 (Posted: Sep 12, 2017 1PM)

The clinical perspective: How to personalise treatment in MS and how may biomarkers including imaging contribute to this?
Vermersch Patrick et al. Multiple sclerosis (Houndmills, Basingstoke, England) 2016 Aug 22(2 Suppl) 18-33 (Posted: Aug 03, 2016 9AM)

Alterations of the human gut microbiome in multiple sclerosis
S Jangi et al, Nature Communications, June 28, 2016 (Posted: Jun 28, 2016 0PM)

Getting a genetic handle on multiple sclerosis
Genomics Education UK, June 6, 2016 (Posted: Jun 08, 2016 10AM)

Multiple sclerosis: genetics, biomarkers, treatments.
Axisa Pierre-Paul et al. Current opinion in neurology 2016 Jun (3) 345-53 (Posted: Jun 02, 2016 1PM)

Linking Genotype to Clinical Phenotype in Multiple Sclerosis- In Search of the Holy Grail
EE Longbrake et al, JAMA Neurology, May 31, 2016 (Posted: Jun 02, 2016 1PM)

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis
N Isobe et al, JAMA Neurology, May 31, 2016 (Posted: Jun 02, 2016 1PM)

From genetic associations to functional studies in multiple sclerosis.
Bos S D et al. European journal of neurology 2016 May (5) 847-53 (Posted: May 24, 2016 11AM)

Some recent advances in multiple sclerosis.
McCarthy Claire et al. Journal of neurology 2016 Apr (Posted: May 24, 2016 11AM)

MSPrecise: A molecular diagnostic test for multiple sclerosis using next generation sequencing.
Rounds William H et al. Gene 2015 Nov 572(2) 191-7 (Posted: Jan 20, 2016 11AM)

Personalized therapy for multiple sclerosis (MS)
Mayo Clinic, December 13, 2015 (Posted: Dec 13, 2015 8PM)

Class II HLA interactions modulate genetic risk for multiple sclerosis
L Moutsianas et al. Nature Genetics, September 7, 2015 (Posted: Sep 07, 2015 7PM)

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study
LE Mokry et al. PLoS Medicine, August 25, 2015 (Posted: Aug 25, 2015 3PM)

Risk factors for multiple sclerosis include family history
from the Mayo CLinic (Posted: Aug 25, 2015 3PM)

Recent advances and future challenges in the genetics of multiple sclerosis.
Lill Christina M et al. Front Neurol 2014 130 (Posted: Aug 25, 2015 2PM)

Differential diagnosis of Mendelian and mitochondrial disorders in patients with suspected multiple sclerosis.
Weisfeld-Adams James D et al. Brain 2015 Mar (Pt 3) 517-39 (Posted: Aug 25, 2015 2PM)

Multiple sclerosis-a quiet revolution.
Ransohoff Richard M et al. Nat Rev Neurol 2015 Mar (3) 134-42 (Posted: Aug 25, 2015 2PM)

Susceptibility variants in the CD58 gene locus point to a role of microRNA-548ac in the pathogenesis of multiple sclerosis.
Hecker Michael et al. Mutat Res Rev Mutat Res 2015 Jan-Mar 161-7 (Posted: Aug 25, 2015 2PM)

Epigenetic changes in neurology: DNA methylation in multiple sclerosis.
Iridoy Zulet M et al. Neurologia 2015 May 11. (Posted: Aug 25, 2015 2PM)

Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?
Ruhrmann Sabrina et al. Int. J. Biochem. Cell Biol. 2015 May 19. (Posted: Aug 25, 2015 2PM)

The immunogenetics of multiple sclerosis: A comprehensive review.
Hollenbach Jill A et al. J. Autoimmun. 2015 Jul 2. (Posted: Aug 25, 2015 2PM)

Biomarkers in multiple sclerosis.
Housley William J et al. Clin. Immunol. 2015 Jul 2. (Posted: Aug 25, 2015 2PM)

Check out genetic tests and conditions associated with multiple sclerosis
from the NIH Genetic Testing Registry Brand (Posted: Aug 25, 2015 2PM)

NIH Information: What is Multiple Sclerosis?
Brand (Posted: Aug 25, 2015 2PM)

Interaction between passive smoking and two HLA genes with regard to multiple sclerosis risk.
Hedström Anna Karin et al. Int J Epidemiol 2014 Dec (6) 1791-8 (Posted: Feb 17, 2015 10AM)

Tumefactive multiple sclerosis
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)

Pediatric multiple sclerosis
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan 01, 2011 0AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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